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KMID : 0617819950050010203
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Journal of Wonkwang Oriental Medicine
1995 Volume.5 No. 1 p.203 ~ p.234
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Effects of Soshiho-Tang on the Production of Free Radicals and Functions of Immunocytes in the Mouse
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Abstract
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Soshiho-tang is one of the well-known oriental medicines for a long time. It is used for the treatment of such diseases as infectious diseases, hepatic diseases and gastroenteritis and so on.
In this study, the author tried to evaluate the effects of Soshiho-tang on the immune system of the mouse. For the effects of Soshiho-tang on the innate immune system, the author measured the classⅡ major histocompatibility complex(MHC) antigen expression, reactive nitrogen and oxygen intermediates productions and phagocytic activity of peritoneal macrophages. For the effects of Soshiho-tang on the T lymphocytes, the author measured the subsets of T lymphocytes after administration of the drug.
The results obtained in this study are as follows :
1. The administration of Soshiho-tang increased the expression of classⅡ MHC antigen in the peritonea macrophages.
2. In vitro exposure of peritoneal macrophages to the Soshiho-tang increased the expression of classⅡ MHC antigen in the peritoneal macrophages.
3. Soshiho-tang triggered the secretion of nitric oxide from murine peritoneal macrophages.
4. The administration of Soshiho-tang decreased the productions of superoxide and hydrogen peroxide from the peritoneal macrophages in the dose dependent fashion.
5. In vitro exposure of peritoneal macrophages to Soshiho-tang decreased the production of superoxide and hydrogen peroxide in the dose dependent fashion.
6. The administration of Soshiho-tang increased the phagocytic activity of peritoneal macrophages.
7. In vitro exposure of peritoneal macrophages to Soshiho-tang increased the phagocytic activity of peritoneal macrophages.
8. The administration of Soshiho-tang did not affect the T cell subsets in the sequestrating peripheral lymph nodes.
The above results suggest that Soshiho-tang could increase the functions of phagocytes without affecting the T cell subsets, and decrease the tissue damaging effect mediated by reactive oxygen intermediates.
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KEYWORD
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